The discovery that particular neutrophil subset and DNA-containing NETs are implicated in the regulation of type 2-mediated allergic asthma is completely novel (Toussaint et al., Nat Med, 2017; Radermecker et al., in revision), and this line of investigation is currently being pursued. Ongoing work is now investigating how neutrophils are imprinted and shaped upon exposure to various 'pro-allergic' and 'protective' environmental conditions. Their contribution, under these circumstances, to the regulation of asthma disease, and the interplay between neutrophils and other innate immune cells will be investigated in order to gather a more comprehensive and integrated view of the innate immune mechanisms influencing allergic asthma development.
