In the lung mucosa, structural and myeloid cells are particularly exposed and responsive to external threats such as pollutants, allergens, microbes or microbial products. Understanding how myeloid cells develop and how these cells interact with structural cells to regulate homeostasis, disease physiopathology and tissue repair responses is of fundamental biological importance and has critical implications for the prevention of immune-mediated disorders such as asthma, chronic obstructive pulmonary disease or viral-triggered immunopathologies. In the Immunophysiology lab, we employ the most recent single cell technologies in combination with innovative transgenic tools and clinically relevant animal models to address this question. We also closely collaborate with clinicians to investigate tissue immunopathology in relevant human clinical material. Also see Research Projects for more information.
