A study in The Journal of Experimental Medicine shows how circulating monocytes detect metabolic signals in the lung to locate macrophage niches and differentiate. The work reveals a potential therapeutic pathway to modulate lung immunity.

MafB, a key genetic regulator that enables macrophages to reach full maturity and preserve the health of our organs, opening up new therapeutic avenues for treating numerous chronic diseases.

This prestigious scientific award, presented in the presence of HM the Queen, will help fund his research on respiratory physiology, particularly the role of pulmonary neutrophils.

A study led by Thomas Marichal's team reveals how signals from endothelial cells lining blood vessels guide the development of interstitial macrophages — immune cells essential for maintaining lung tissue integrity.

A recently identified population of macrophages has been found to play a crucial role in alveolar regeneration, with the potential to reduce complications from severe respiratory infections and Acute Respiratory Distress Syndrome (ARDS).

The aim of this project is to study the behaviour of innate immune cells following pulmonary viral infections in order to develop new targeted therapeutic strategies.

Thomas Marichal’s team publishes in Nature Immunology this fundamental discovery that suggests a greater involvement of cell proliferation in the functioning of our immune system