Laboratory of Immunophysiology
Our lab aims to investigate the development, trajectory, biology and functions of myeloid cells in health and disease, with a particular interest in the lung mucosa and in lung chronic inflammatory disorders.
News & Events
RESEARCH PROJECTS
Four GIGA projects supported by the WELBIO Investigator Program
The WELBIO Investigator Program 2025, funded by the Walloon Region to support strategic research programs of excellence, has selected projects by Julien Guiot (Starting Grant), Pierre Close, Thomas Marichal, and Laurent Nguyen (Advanced Grants).
Publication in The Journal of Experimental Medicine
Metabolic signals guide the formation of lung macrophages
A study in The Journal of Experimental Medicine shows how circulating monocytes detect metabolic signals in the lung to locate macrophage niches and differentiate. The work reveals a potential therapeutic pathway to modulate lung immunity.
A publication in Immunity
A universal "instruction manual" helps immune cells protect our organs
MafB, a key genetic regulator that enables macrophages to reach full maturity and preserve the health of our organs, opening up new therapeutic avenues for treating numerous chronic diseases.
Video
Health Research at GIGA ULiege - Lung Immunophysiology
Discover the research topics addressed in the laboratory of Immunophysiology (GIGA-I3).
Research
Mo-Mac-TrajectALI
Monocyte-to-Macrophage Trajectories After Lung Injury: Spatio-temporal investigation, molecular regulation & functional implications for lung regeneration and immunity
Decode VirAttacks
Deciphering the contribution of the myeloid-epithelial crosstalk to viral-induced exacerbations of chronic airway diseases: an inescapable path towards precision medicine and improved quality of life
Last publication
MafB is a conserved transcriptional regulator of macrophage development and functional identity across tissues and species in Immunity. Free-access reprint link to the paper: https://authors.elsevier.com/a/1mgne3qNrV3VZG
MotroRepair
Atypical myeloid cells emerging during the recovery phase of respiratory viral infections: origin, identity, functions and regulation by tissue cues, host risk factors and chronic stress.
Thomas Marichal, DVM, PhD
Welbio & F.R.S.-FNRS Permanent Investigator
Immunophysiology Lab
GIGA-Research B34, University of Liege,
Quartier HOPITAL
Avenue de l’Hôpital, 11, 4000 Liège
t.marichal@uliege.be
+ 32 4 366 95 55
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